Is it safe? Is it not safe? What exactly is Rapamycin? Why even use it, how does it work? What is the research? It is worth the hype? What's the cost? What are the benefits? How should I use it? These are all questions you may be asking yourself when you hear about the relatively new and mysterious drug called, rapamycin. So without further ado, here's everything you need to know about Rapamycin in 3 minutes or less!
What is Rapamycin?
Rapamycin (also known as sirolimus) is a longevity drug and first discovered around the 1970s. It is a very rare "life protecting" substance found inside special bacteria on Easter Island. It is important to note that animals and humans and many other types of life forms cannot make rapamycin. But they CAN benefit from it since it is a very powerful regulator of growth and protection.
How does Rapamycin work for longevity?
Rapamycin inhibits the activity of mTOR inside the human body. mTOR is responsible for accelerating growth, but also accelerating aging. This is not as big of a concern for those who are still young, but slowing down the activity of mTOR in older populations can significantly stop the "breaking down" of cells, DNA, and the human body. Supplementing with rapamycin could be a potential fountain of youth as it can help people stay younger, live longer and stop, or at least protect against, aging and it's "harmful" side-effects.
Is Rapamycin safe?
Rapamycin was approved by the U.S. Food and Drug Administration (FDA) in September 1999. It is just as safe as "any other drug"; in fact, it was initially developed as an antifungal agent and has been successfully used as an immunomodulator and anti-inflammatory drug, too. It can even help people with various organ, cancer, and cardiorespiratory illnesses.
Are you saying there are no risks?
There are very few documented risks of rapamycin use in healthy populations when used correctly. And keep in mind many claims of severe risks are undocumented. The most adverse reactions are observed in very ill populations, and those taking rapamycin after organ transplants. Some of these adverse reactions include: Sore or inflamed mouth, weakened immune system, anemia and fatigue, constipation or diarrhea, elevated cholesterol or lipid levels, high blood pressure, and swollen hands and feet.
What are the dosing recommendations?
Rapamycin is taken orally as a tablet, or liquid solution, for people who can’t swallow pills. It can be taken with food or a large glass of water or orange juice. Keep in mind rapamycin is not safe to take with grapefruit juice. However, if you take rapamycin, be sure to take it at the same time and in the same way each day. For cancer patients, rapamycin treatment is given through an IV.
NOTE: There is no one "right" dose. Improper dosing can obviously lead to increased risks, so you must talk with your healthcare provider as they will adjust the dose based on how your body tolerates it, how it affects any existing medical condition(s), and whether you’re experiencing side effects. They may decide to increase the dose, decrease it, or switch you to a different medication altogether.
What says the research?
The upshot is that, yes, it can slow down aging and many age-related diseases. Much of the research has been done on mice with some incredible results. In one study, mice given the drug lived 3x longer than those who received no pill at all. Another study mentions the use of rapamycin to mice living the equivalent of 140 human years. Given the pathways of its action, it can improve and protect also against negative changes in immunity, brain health, neurology, chronic diseases, general health and wellness, and more. You can find a bunch of research studies here and more info here by also searching more about the topic online.
Is it worth the hype?
A "full" year of supply could cost somewhere between $80 to $150, so it may very well be something most would consider worth the benefits or hype. There are also lower costs options under development that will eventually become available to the public from select sources, so that's also good news! Remember dosing is on an induvial basis; so, make sure to consult a certified longevity expert for a recommended dosing plan.
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