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Sirolimus Whole Blood Serum Assessment

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Regular price $55.00
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Specimen Requirements


Specimen

Whole blood


Volume

3 mL


Minimum Volume

1.1 mL


Container

Lavender-top (EDTA) tube


Collection

Trough: 30 minutes to one hour before the next oral dose


Storage Instructions

Room temperature


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Patient Preparation

Trough levels are most reproducible.


Causes for Rejection

Clotted specimen


Test Details


Use

Monitor immunosuppressive therapy following organ transplant


Limitations

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)


Reference Interval

3.0−20.0 ng/mL


Additional Information

Sirolimus may be administered in conjunction with cyclosporine (CsA) and corticosteroids to reduce or prevent host graft rejection. Using this therapy, peak concentrations are achieved in one to two hours. The mean terminal elimination half-life is 62 hours.1 Drug-drug interactions, including CsA, may alter the pharmacokinetics of sirolimus, making therapeutic drug monitoring appropriate.

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