The Amino Acid Solution for Peak Performance & Recovery. Even Weight Loss, Depression, Fatigue, Insomnia, Osteoporosis, Kidney Health, and So Much More.
A VERY Deep Dive Into Clinical Amino Acid Studies!
Proteins are the cornerstone of human physiology, forming the foundation upon which the body operates. Nevertheless, a majority concerning number of individuals find themselves (proven by clinical research) afflicted by a shortage of crucial amino acids, indispensable for the synthesis of proteins. This insufficiency can precipitate a myriad of health issues ranging from metabolic disorders like diabetes and obesity to severe conditions such as cancer and chronic ailments. Rectifying this deficiency demands a substantial increase in the intake of dietary proteins – surpassing conventional guidelines by 4-6x times – to account for losses during the digestive process and the possibility of excessive calorie consumption. Alternatively, embracing the cutting-edge advancements in biomedical science offers a viable solution in the form of essential amino acid supplements such as FundAminos. Essential amino acid supplements represent a remarkable answer to the nutritional protein deficit dilemma, furnishing the body with the precise elements and ratios of protein required for optimal health and functionality, with only 5 calories and at 4x-6x more effectiveness and 8x-16x quicker working for health, performance, and recovery than dietary protein. No brainer, right? Let's learn so much more in the studies below!!!
Study results show that a 51-year-old female athlete, while taking the essential amino acids as a sole and total substitute for dietary protein, and performing physical activity, experienced (1) increased body muscle mass, strength, and endurance; (2) decreased body fat mass; (3) greater increase in performance of the nonprevailing muscles compared to the prevailing muscles; (4) improved cardiorespiratory performance; and (5) increased red blood cells, hemoglobin, and hematocrit parameters. It was concluded, confirming previous findings, that use of amino acids as a sole and total substitute for dietary protein, in conjunction with physical activity, provides safer, unprecedented optimization of the body’s protein synthesis, thereby improving anthropometric characteristics and physical and physiologic performance.
Sharp, CPM and Pearson, DR. Amino acid supplements and recovery from high-intensity training. J Strength Cond Res 24(4): 1125-1130, 2010-The purpose of this study was to investigate whether short-term amino acid supplementation could maintain a short-term net anabolic hormonal profile and decrease muscle cell damage during a period of high-intensity resistance training (overreaching), thereby enhancing recovery and decreasing the risk of injury and illness. Eight previously resistance trained males were randomly assigned to either a high branched chain amino acids (BCAA) or placebo group. Subjects consumed the supplement for 3 weeks before commencing a fourth week of supplementation with concomitant high-intensity total-body resistance training (overreaching) (3 × 6-8 repetitions maximum, 8 exercises). Blood was drawn prior to and after supplementation, then again after 2 and 4 days of training. Serum was analyzed for testosterone, cortisol, and creatine kinase. Serum testosterone levels were significantly higher (p < 0.001), and cortisol and creatine kinase levels were significantly lower (p < 0.001, and p = 0.004, respectively) in the BCAA group during and following resistance training. These findings suggest that short-term amino acid supplementation, which is high in BCAA, may produce a net anabolic hormonal profile while attenuating training-induced increases in muscle tissue damage. Athletes' nutrient intake, which periodically increases amino acid intake to reflect the increased need for recovery during periods of overreaching, may increase subsequent competitive performance while decreasing the risk of injury or illness.
Despite decades of use of low protein diets (LPD) in the management of chronic kidney disease (CKD), their mechanisms of action are unclear. A reduced production of uremic toxins could contribute to the benefits of LPDs. Aromatic amino-acids (AA) are precursors of major uremic toxins such as p-cresyl sulfate (PCS) and indoxyl sulfate (IS). We hypothesize that a low aromatic amino acid diet (LA-AAD, namely a low intake of tyrosine, tryptophan and phenylalanine) while being normoproteic, could be as effective as a LPD, through the decreased production of uremic toxins. Kidney failure was chemically induced in mice with a diet containing 0.25% (w/w) of adenine. Mice received three different diets for six weeks: normoproteic diet (NPD: 14.7% proteins, aromatic AAs 0.019%), LPD (5% proteins, aromatic AAs 0.007%) and LA-AAD (14% proteins, aromatic AAs 0.007%). Both LPD and LA-AAD significantly reduced proteinuria, kidney fibrosis and inflammation. While LPD only slightly decreased plasma free PCS and free IS compared to NPD; free fractions of both compounds were significantly decreased by LA-AAD. These results suggest that a LA-AAD confers similar benefits of a LPD in delaying the progression of CKD through a reduction in some key uremic toxins production (such as PCS and IS), with a lower risk of malnutrition.
Sleep disorder significantly affects the life quality of a large number of people but is still an underrecognized disease. Dietary nutrition is believed to play a significant impact on sleeping wellness. Low protein can contribute to increased stress, hormonal disruptions, erratic circadian rhythm, less deep sleep REM, and Many nutritional supplements have been used trying to benefit sleep wellness. However, the relationship between nutritional components and sleep is complicated. Nutritional factors vary dramatically with different diet patterns and depend significantly on the digestive and metabiotic functions of each individual. Moreover, nutrition can profoundly affect the hormones and inflammation status which directly or indirectly contribute to insomnia. In this review, we summarized the role of major nutritional factors, carbohydrates, lipids, amino acids, and vitamins on sleep and sleep disorders and discussed the potential mechanisms
Dietary proteins have been used for years to treat obesity. Body weight loss is beneficial when it concerns fat mass, but loss of fat free mass – especially muscle might be detrimental. This occurs because protein breakdown predominates over synthesis, thus administering anabolic dietary compounds like proteins might counter fat free mass loss while allowing for fat mass loss.
Indeed, varying the quantity of proteins will decrease muscle anabolic response and increase hyperphagia in rodents fed a low protein diet; but it will favor lean mass maintenance and promote satiety, in certain age groups of humans fed a high protein diet. Beyond protein quantity, protein source is an important metabolic regulator: whey protein and plant based diets exercise favorable effects on the risk of developing obesity, body composition, metabolic parameters or fat free mass preservation of obese patients. Specific amino-acids like essential (EAA) and branched chain amino acids (BCAA), like methionine, tryptophan and its metabolites, and glutamate can also positively influence parameters and complications of obesity especially in rodent models, with less studies translating this in humans.
Tuning the quality and quantity of proteins or even specific essential and branched-chain amino-acids can thus be seen as a potential therapeutic intervention on the body composition, metabolic syndrome parameters and appetite regulation of obese patients. Since these effects vary across age groups and much of the data comes from murine models, long-term prospective studies modulating proteins and amino acids in the human diet are needed.
Emerging research findings support that amino acid supplementation may be a safe and effective treatment of depressed mood. To date, most human clinical trials have investigated single amino acids such as 5-HTP or l-tyrosine, and have not examined complex relationships between 5-HTP and l-tyrosine or other amino acids that may play important roles in synthesis of neurotransmitters involved in mood regulation. A balanced approach to amino acid supplementation with 5-HTP and l-tyrosine, the essential precursors of serotonin and dopamine, may provide an important integrative strategy for management of depressed mood. Achieving optimal antidepressant response using this approach involves finding the optimal balance of amino acids. Large placebo-controlled studies conducted by independent researchers are needed to elucidate complex relationships between amino acid precursors and neurotransmitters involved in mood regulation, and to determine practical, safe strategies for amino acid supplementation for management of depressed mood and possibly other psychiatric disorders.
Amino Acids for Chronic Fatigue
There is an increasing interest in the mechanisms behind central fatigue, particularly in relation to changes in brain monoamine metabolism and the influence of specific amino acids on fatigue. Several studies in experimental animals have shown that physical exercise increases the synthesis and metabolism of brain 5-hydroxytryptamine (5-HT). Support for the involvement of 5-HT in fatigue can be found in studies where the brain concentration of 5-HT has been altered by means of pharmacological agents. When the 5-HT level was elevated in this way the performance was impaired in both rats and human subjects, and in accordance with this a decrease in the 5-HT level caused an improvement in running performance in rats. The precursor of 5-HT is the amino acid tryptophan and the synthesis of 5-HT in the brain is thought to be regulated by the blood supply of free tryptophan in relation to other large neutral amino acids (including the branched-chain amino acids, BCAA) since these compete with tryptophan for transport into the brain. Studies in human subjects have shown that the plasma ratio of free tryptophan/BCAA increases during and, particularly, after sustained exercise. This would favour the transport of tryptophan into the brain and also the synthesis and release of 5-HT which may lead to central fatigue. Attempts have been made to influence the 5-HT level by giving BCAA to human subjects during different types of sustained heavy exercise. The results indicate that ingestion of BCAA reduces the perceived exertion and mental fatigue during exercise and improves cognitive performance after the exercise. In addition, in some situations ingestion of BCAA might also improve physical performance; during exercise in the heat or in a competitive race when the central component of fatigue is assumed to be more pronounced than in a laboratory experiment. However, more experiments are needed to further clarify the effect of BCAA and also of tryptophan ingestion on physical performance and mental fatigue.
Age-induced osteoporosis is a global problem. Essential amino acids (EAAs) work as an energy source and a molecular pathway modulator in bone, but their functions have not been systematically reviewed in aging bone. This study aimed to discuss the contribution of EAAs on aging bone from in vitro, in vivo, and human investigations. In aged people with osteoporosis, serum EAAs were detected changing up and down, without a well-established conclusion. The supply of EAAs in aged people either rescued or did not affect bone mineral density (BMD) and bone volume. In most signaling studies, EAAs were proven to increase bone mass. Lysine, threonine, methionine, tryptophan, and isoleucine can increase osteoblast proliferation, activation, and differentiation, and decrease osteoclast activity. Oxidized L-tryptophan promotes bone marrow stem cells (BMSCs) differentiating into osteoblasts. However, the oxidation product of tryptophan called kynurenine increases osteoclast activity, and enhances the differentiation of adipocytes from BMSCs. Taken together, in terms of bone minerals and volume, more views consider EAAs to have a positive effect on aging bone, but the function of EAAs in bone metabolism has not been fully demonstrated and more studies are needed in this area in the future.
Amino acids do so much for you, but here are the top 10 most important functions:
1. Providing the body with energy
Isoleucine and valine, in particular, are good sources of energy to fuel the body.
2. Enhancing the musculoskeletal system
Isoleucine and valine assist with healthy muscle function, while leucine works to repair muscles. Lysine promotes calcium absorption needed for bone growth. These amino acids are good for healthy, toned muscles and strong bones. Isoleucine and valine are common ingredients in workout supplements because they target the muscles and boost energy.
3. Regulating digestion
Your body produces histamine to help your digestive system work properly. You need histamine to histidine to help generate histamine.
4. Enforcing healthy sleep/wake cycles
Erratic sleep habits caused by issues such as insomnia, sleep apnea, and stress, can take a toll on your overall health. Histidine and tryptophan help you maintain normal circadian rhythms for a good night’s sleep.
5. Supporting the immune system
Want to keep colds and flu at bay? histidine, lysine, and threonine help boost immunity so your body can better fight off viruses.
6. Producing neurotransmitters
These chemicals are the nervous system’s way of communicating with the body, regulating everything from appetite to mood. Phenylalanine not only produces some neurotransmitters but other types of amino acids, too.
7. Stimulating the growth of healthy skin, nails, and hair
Collagen and elastin keep your complexion looking soft and supple. These two proteins also encourage hair and nail growth. Lysine assists with collagen production, while threonine helps generate collagen and elastin.
8. Producing hormones
Amino acids such as lysine are useful for maintaining healthy hormone levels. Examples of amino acid hormones include epinephrine and norepinephrine, which oversee the body’s stress response, and thyroxine, which plays a role in metabolism.
9. Maintaining a healthy weight
Methionine governs our metabolic rate and can also help with detoxification, while threonine is key for metabolizing fat.
10. Balancing your moods
Tryptophan jump-starts the production of serotonin, a hormone that’s essential for feeling happy and well-adjusted.
Amino acids benefit your well-being, which means it’s crucial to make sure you get enough of them in your daily diet. Essential amino acids are found in many foods, such as beef, eggs, nuts, fish, and beans. Some people rely on amino acid supplements to ensure adequate intake. However, other people may be deficient. Given what amino acids do for your body, you won’t feel your best if you’re low on this vital nutrient. That’s why many people turn to IV therapy.
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