The Benefits of Proline, and How to Get it in Your Diet.

Get the news on a NEW STUDY about proline, very cutting-edge news! This was NOT expected to be so positive! They key points to take away are that proline is something you can only obtain in adequate amounts from collagen. Proline mitigates several aging hallmarks, including DNA damage, senescence-associated β-galactosidase, inflammatory cytokine expressions, and impaired myogenic differentiation capacity. Those who do not eat adequate collagen are rapidly accelerating their aging, and that's REALLY BAD!  You can get proline from some plants, seeds, nuts, and vegan foods, but they are very small amounts. In soy protien, you get only 5 grams per 100 grams. But in PureClean Protein, for example, you get 36 grams per 100 grams. This makes PureClean Protein powder dual protein matrix packed with 21g protein plus 12g collagen with proline a very effective anti-aging protein powder.

Proline restores mitochondrial function and reverses aging hallmarks in senescent cells

Mitochondrial dysfunction is a hallmark of cellular senescence, with the loss of mitochondrial function identified as a potential causal factor contributing to senescence-associated decline in cellular functions. Our recent findings revealed that ectopic expression of the pluripotency transcription factor NANOG rejuvenates dysfunctional mitochondria of senescent cells by rewiring metabolic pathways. In this study, we report that NANOG restores the expression of key enzymes, PYCR1 and PYCR2, in the proline biosynthesis pathway. Additionally, senescent mesenchymal stem cells manifest severe mitochondrial respiratory impairment, which is alleviated through proline supplementation. Proline induces mitophagy by activating AMP-activated protein kinase α and upregulating Parkin expression, enhancing mitochondrial clearance and ultimately restoring cell metabolism. Notably, proline treatment also mitigates several aging hallmarks, including DNA damage, senescence-associated β-galactosidase, inflammatory cytokine expressions, and impaired myogenic differentiation capacity. Overall, this study highlights the role of proline in mitophagy and its potential in reversing senescence-associated mitochondrial dysfunction and aging hallmarks.

Read the full study here. https://doi.org/10.1016/j.celrep.2024.113738