The Healing of Lumbrokinase Enzymes

Lumbrokinase enzyme is a powerful proteolytic enzyme derived from earthworms, known for its impressive health benefits. This enzyme has been extensively studied and has shown promising results in various health conditions. Some of the key benefits of lumbrokinase enzyme include its ability to support cardiovascular health by promoting healthy blood circulation and preventing the formation of blood clots and tissue scarring. Additionally, lumbrokinase enzyme has anti-inflammatory properties, making it a valuable supplement for reducing inflammation and promoting overall wellness. Furthermore, this enzyme has been found to support immune function and improve overall digestion. Overall, lumbrokinase enzyme is a natural and effective way to enhance health and well-being. Read more about this in the study below and, after. check out the top trusted, and a good discount, Lumbrokinase Enzymes from Dr. Cohen's MLP Formulary

Lumbrokinase, a Fibrinolytic Enzyme, Prevents Intra-Abdominal Adhesion by Inhibiting the Migrative and Adhesive Activities of Fibroblast via Attenuation of the AP-1/ICAM-1 Signaling Pathway

Abstract

Intra-abdominal adhesion is a complication following abdominal surgery caused by the suppression of fibrinolytic activity and aggravated fibroblast invasion of the injured area, which may lead to chronic illnesses such as chronic pain, intestinal obstruction, and female infertility. This study hypothesized that lumbrokinase, a fibrinolytic enzyme extracted from the earthworm, supports the wound healing process. Therefore, we assessed the effect of lumbrokinase on intra-abdominal adhesion. Lumbrokinase treatment significantly decreased the severity and the area of intra-abdominal adhesion in vivo in a dose-dependent manner compared with the controls (untreated and hyaluronate-treated). Lumbrokinase-associated adverse effects were not observed. Immunohistochemical analysis of adhesion tissues revealed a loosened adhesive band between tissues, coupled with significantly decreased peritoneal thickening in the lumbrokinase-treated group versus the control group. Three-dimensional spheroid, MTT, and scratch wound migration assays using the IMR-90 human fibroblast cell line demonstrated that lumbrokinase significantly attenuated the migration and adhesive activity of fibroblasts without compromising cell proliferation. The luciferase assay and western blot analysis showed that lumbrokinase inhibited the AP-1/ICAM-1 cell adhesion signaling pathway. Therefore, lumbrokinase decreases intra-abdominal adhesion and peritoneal thickening by augmenting fibrinolytic action and inhibiting fibroblast migration and adhesive activity via attenuation of the AP-1/ICAM-1 signaling pathway. Lumbrokinase is thus a promising agent to prevent intra-abdominal adhesion.

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