David Sinclair Supplements: Are They Worth It?
Last Updated: September 6, 2024 | Published: September 6, 2024
David Sinclair's Supplement Stack
David Sinclair, a leading researcher in the field of aging and longevity, has popularized a supplement regimen that aims to slow down the aging process, enhance cellular health, and extend lifespan. Based on his interviews, publications, and ongoing research, Sinclair’s supplement stack includes a variety of ingredients, some of which have strong scientific backing, while others require further study. But how effective are these supplements in practice, and are they worth considering?
1. Nicotinamide Mononucleotide (NMN)
Dosage: 1g per day in the morning
Benefits: NMN boosts NAD+ (Nicotinamide Adenine Dinucleotide) levels in the body, a molecule crucial for energy production, DNA repair, and cell maintenance. NAD+ levels decline with age, and increasing NAD+ through NMN supplementation is thought to support longevity, improve metabolic health, and delay the onset of age-related diseases.
Considerations: While research on NMN is promising, particularly in animal studies, long-term human studies are still lacking. Moreover, the body’s ability to absorb NMN efficiently is still a topic of debate.
2. Resveratrol
Dosage: 1g per day in the morning
Benefits: Resveratrol, an antioxidant found in red wine, is believed to combat oxidative stress, support cardiovascular health, and possibly promote longevity by mimicking the effects of calorie restriction. It has also been linked to activating certain longevity pathways, such as SIRT1.
Considerations: Though promising in animal studies, resveratrol has mixed results in human trials, especially regarding its bioavailability. The body doesn’t absorb resveratrol well, meaning its benefits may not be as significant as initially thought especially if taken in pill form.
3. Metformin
Dosage: 800 mg per day in the evening
Benefits: Originally developed as a treatment for type 2 diabetes, metformin has been shown to improve insulin sensitivity, lower blood sugar, and activate AMPK, a protein linked to cellular longevity. Some studies also suggest it may have anti-aging effects.
Considerations: Metformin is a prescription medication with potential side effects, including gastrointestinal discomfort and vitamin B12 deficiency. While it shows promise in aging research, it’s not without its risks, and its use should be under medical supervision.
4. Vitamin D3
Dosage: 4,000 to 5,000 IU per day
Benefits: Vitamin D is crucial for bone health, immune function, and cellular processes. It also helps regulate calcium and phosphorus in the body, supporting cardiovascular health. Supplementing with vitamin D3 is important for those with low levels, particularly in areas with limited sunlight.
Considerations: Excessive vitamin D can lead to toxicity, but the dosage Sinclair recommends (4,000 to 5,000 IU) is generally safe for most individuals. It’s always best to check vitamin D levels through a blood test before starting supplementation.
5. Vitamin K2
Dosage: 180 to 360 micrograms per day
Benefits: Vitamin K2 works synergistically with vitamin D3 to promote healthy calcium metabolism, ensuring that calcium is deposited in bones rather than arteries. This helps prevent arterial calcification, a risk factor for heart disease.
Considerations: Vitamin K2 is generally safe when taken in appropriate amounts, but it can interfere with blood-thinning medications like warfarin.
6. Statins
Dosage: Not specified, but typically low-dose
Benefits: Statins are used to lower cholesterol and reduce the risk of heart disease. There is some evidence suggesting statins may have a role in longevity by reducing inflammation and lowering oxidative stress.
Considerations: Statins come with a range of side effects, including muscle pain, liver damage, and digestive issues. They are best taken under the supervision of a healthcare provider.
7. Low-Dose Aspirin
Dosage: 83 mg per day
Benefits: Aspirin is widely used for its anti-inflammatory properties and is often prescribed for cardiovascular protection. Recent studies have suggested it may also lower cancer risk by reducing inflammation.
Considerations: Daily aspirin use increases the risk of bleeding, particularly gastrointestinal bleeding. It's essential to consult with a doctor before starting aspirin therapy, especially for those with a history of ulcers or other bleeding disorders.
8. Alpha Lipoic Acid (ALA) and Coenzyme Q10 (CoQ10)
Dosage: Status unknown
Benefits: ALA and CoQ10 are antioxidants that help protect cells from oxidative damage and support mitochondrial function. ALA also helps with glucose metabolism, while CoQ10 is crucial for energy production in cells.
Considerations: Both supplements are generally safe but may interact with certain medications, especially blood thinners. The benefits of ALA and CoQ10 for aging are promising and under investigation.
9. Spermidine
Dosage: 1 mg per day in the morning
Benefits: Spermidine is a polyamine that supports autophagy, the body's process of cleaning out damaged cells and recycling cellular components. It's believed to have a role in longevity by improving cellular function and reducing inflammation.
Considerations: Spermidine supplementation is being studied, and while initial research is promising.
10. Quercetin and Fisetin
Dosage: 500 mg each per day in the morning
Benefits: Both of these flavonoids are antioxidants that may help reduce inflammation and promote cellular health. They have also shown potential as senolytics, compounds that target and remove aging or damaged cells.
Considerations: Quercetin and fisetin are generally well tolerated, but their effectiveness as senolytics is still being studied, and more research is needed to confirm these combined benefits.
11. Trimethylglycine (TMG)
Dosage: 500 mg to 1,000 mg per day
Benefits: TMG, also known as betaine, supports methylation, a crucial process for gene expression and detoxification. It may also help reduce homocysteine levels, which are associated with cardiovascular health.
Considerations: TMG is generally safe, but it can cause gastrointestinal issues in some people at higher doses.
Are David Sinclair’s Supplements Worth It?
David Sinclair’s supplement regimen includes a variety of scientifically supported ingredients that target different aspects of aging and cellular health. Some of these supplements, like NMN, resveratrol, and metformin, have promising research behind them, particularly in animal studies. However, much of the human data remains inconclusive, and the long-term effects are still unknown.
For those who are keen on longevity and cellular health, Sinclair’s stack offers a comprehensive approach, but it’s important to weigh the potential benefits against the cost and risks, particularly with prescription medications like metformin and statins. Consulting with a healthcare provider before starting this regimen is crucial, especially considering the potential for side effects.
Comparison with PureClean Performance’s and Dr. Cohen's MLP Products
PureClean Performance offers a range of supplements, including RCP (Rejuvenation Complex Protocol) and MLP (Maximum Longevity Protocol) products, that focus on enhancing overall health, energy, and longevity. While these products don’t feature the exact same ingredients as Sinclair's stack, they emphasize natural, science-backed supplements that promote wellness. To learn more please click the links below: