Methylene blue was first prepared in 1876, by Heinrich Caro. It is on the World Health Organization's List of Essential Medicines. A main use of methylene blue in modern bio-hacking is to improve the oxygenation capabilities of mitochondria so that they can have more energy and thus so you have more energy, health, wellness, and more!
It is also a powerful antioxidant. Typical uses of this methylene blue are: cyanide poisoning, to dye or stain, toxicity, and shock.
The best way to take it is with a concentrated powder or drops. Make sure you are taking human grade and use the correct measuring scoop if using powder to avoid overdosing. Consult your medical professional for dosing.
Check out some more info in these videos below and an more educational content below the videos.
Methylene blue (brand name: Provayblue) is an over-the-counter and prescription medication (prescriptions are required for injections). It may be able to help with a variety of conditions, including methemoglobinemia, malaria, chronic infections like Lyme disease, long-COVID, and even Alzheimer’s disease.
Methylene blue (MB) started as a dye in the 1800s, notably used to treat malaria in the 1890s. Today, MB is primarily used to treat methemoglobinemia.
Recent studies suggest that methylene blue, at low doses, can act as a powerful antioxidant and improve mitochondrial function and the ability for our cells to produce energy. That’s why many people have been using it as a brain-boosting, nootropic supplement.
Additional benefits of MB include promoting youthful skin, getting rid of nail fungus, treating chronic infections, and treating shock.
Is methylene blue still used? Yes, methylene blue is still used in diagnostic procedures to identify abnormal cells. It has a signature blue staining and is used to treat several disorders, such as methemoglobinemia.
MB is most frequently prescribed to treat methemoglobinemia and, occasionally, malaria or cyanide poisoning.
Is methylene blue harmful? Methylene blue is not dangerous for most people in small doses. Individuals taking certain antidepressants, opioids, or antihistamines should not take MB. Pregnant people or those with a G6PD deficiency should also stay clear of MB.
It’s not recommended to take MB simultaneously with other antidepressants. If you take medications to stabilize your mood, discuss all current medications with your doctor before starting a new medication, such as methylene blue.
Although most Lyme disease patients are cured after 2-4 weeks of antibiotics, up to 20% of patients don’t heal so quickly. Methylene blue is a potential alternative treatment for individuals who don’t see success with antibiotics.
Combining methylene blue with certain antibioticsincreases the effectivenessof the antibiotics that fight Lyme disease. Studies have also shown that combining methylene blue with antibiotics is more effective than antibiotics alone to treat Bartonella infections.
Methemoglobinemia is a blood disorder that may result in headache, dizziness, nausea, or skin discoloration. Methylene blue is an FDA-approved treatment for this mostly genetic condition that can turn your blood the color of chocolate.
Certain medications or chemicals can also cause high methemoglobin levels. MB converts ferric iron in your hemoglobin into ferrous iron, thus treating the condition.
Methylene blue’s most mainstream use is treating methemoglobinemia, for which your healthcare provider can prescribe an MB injection.
Methylene blue may be able to treat malaria. The first use of methylene blue was as a malaria treatment in the 1800s. Although largely replaced by alternatives like chloroquine, healthcare providers recently reintroduced MB as a malaria treatment.
This 2018 systematic review shows that “MB has substantial antimalarial activity against all types of malaria in various endemic areas” in Africa, where malaria is most prevalent.
8. Ifosfamide-induced encephalopathy
Ifosfamide is a chemotherapy medication. Encephalopathy is a brain condition that may occur in as many as 40% of individuals who take ifosfamide. There is no agreed-upon treatment for Ifosfamide-induced encephalopathy.
Methylene blue may effectively treat ifosfamide-induced encephalopathy. A 2021 study of 38 people concluded MB to be an effective treatment in as many as 75% of patients.
Methylene blue consistently raises blood pressure. Shock occurs when your blood pressure is dangerously low. MB is, therefore, a promising treatment for shock (such as post-cardiothoracic-surgery shock called vasoplegic syndrome).
Low blood pressure during shock impacts your brain, kidneys, and heart. Doctors may administer MB to raise blood pressure when vasopressors aren’t working.
MB can help with low blood pressure and related conditions, such as vasoplegia. Individuals with high blood pressure should be very wary of taking MB.
10. Nail Fungus
Methylene blue may help with fungal infections, similar to bacterial infections.
This 2014 study shows that when combined with red LED light, MB effectively treats “distal and lateral toenail onychomycosis” (AKA nail fungus).
Where To Get Methylene Blue
Prescription MB is available through your healthcare provider for injectable or intravenous methylene blue.
Several groups should not take methylene blue, including:
Newborns: MB has led to multiple adverse side effects in neonates not seen in adults. Newborns should not take MB.
Pregnant women: There is some evidence that MB can result in fetal death when administered to the mother in the second trimester. Inadvertent MB exposure in the first trimester may not cause as much fetal damage.
Nursing mothers: Methylene blue will likely transfer to breast milk. There is not enough evidence to show whether MB is dangerous to infants, so it’s best for breastfeeding mothers not to risk it.
Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency: MB can cause hemolytic anemia in G6PD-deficiency individuals. Some scientists say G6PD deficiency should contraindicate methylene blue. MB should be used cautiously and judiciously in the case of G6PD deficiency.
People taking antidepressants, as the combination can increase serotonin levels to a dangerous degree.
Do not take methylene blue with any of the following medications:
Specific depression or anxiety medications: Methylene blue may help with depression. Be aware, when paired with certain other antidepressants or antianxiety drugs, methylene blue may lead to serotonin toxicity. These include selective serotonin reuptake inhibitors (SSRIs) bupropion, clomipramine, duloxetine, fluoxetine, mirtazapine, sertraline, and venlafaxine.
Monoamine oxidaseinhibitors (MAOIs): Monoamine oxidase A is an enzyme responsible for breaking down serotonin in the brain. MAOIs like selegiline may interact poorly with methylene blue’s additional impact on serotonin.
Certain antihistamines: MB has a severe interaction with cyproheptadine, an antihistamine meant to treat headaches, motion sickness, and allergic reactions.
Some opioids: Certain opioids, such as buprenorphine, oliceridine, and tapentadol, lead to moderate drug interactions with MB.
St. John’s wort: This herbal supplement treats many conditions, but its antidepressant effects don’t mix well with methylene blue.
Lithium: Lithium is relatively natural for treating depression, but MB plus lithium may lead to serotonin toxicity.
Herbs, dietary supplements, non-prescription drugs, tobacco, alcohol, and illegal drugs may also negatively interact with methylene blue. Talk with your healthcare provider for specific instructions.
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